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Definition 1 (Segment Graph Properties): any two adjacent edges e and f in G are characterized by: (i) they share the same intermediary splice site (adjacency) (ii) they express describe the transcript exon-intron structures of all transcripts spanning s (completeness) (iii) they either differ in mode or in supporting transcripts (discrimationdiscrimination) |
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Figure 1: segment graph inferred on an alternatively spliced locus. (A) The exon-intron structure of a locus with two alternative transcripts. (B) Segment graph elements with links by exonic edges shown as solid arrows, links by intronic edges as dashed arrows, and source/sink links as dotted arroes. (C) Expansion of the segment graph by super-edges coalesced from adjacent exon segments or from splice junctions. (D) Super-edges formed by paired-end mappings within the bounds of the three windows marked, to keep (super-) edge combinations within graphical resolution bounds. |
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