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Similar to the concept of splicing graphs [Heber 2002], we employ a graph structure  for representing the reference transcriptome that is quantified in a non-redundant data structure. Each edge  represents a segment of an annotated pre-mRNA molecule by the genomic coordinate of the corresponding 3'-tail and 5'-head position, by the type (exonic or intronic), and by the set  of supporting transcripts (Lemma Definition 1).

 Lemma Definition 1 (Segment Graph Properties): any two adjacent edges e and f in G are characterized by:

(i) do share the same intermediary splice site  (adjacency)

(ii) explain the transcript structures of all transcripts (completeness)

(iii) either differ in mode or in supporting transcripts (discrimation)